28 July 2013 Last updated at 18:19 ET 
The coach hit several cars before coming off a flyover near the town of Avellino, in the Campania region.
The driver is thought to be among the dead, according to the Italian news agency Ansa.
There were about 40 passengers on board, including children, the news agency said.
The group had been returning to Naples following a pilgrimage.
“I cannot yet confirm the number of victims – we are still pulling people from the vehicle,” a police spokesman told the French news agency AFP.
He added that the Naples-Bari highway had been closed to traffic because of the accident.
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Seven dead in Italy coach crash
